Day 1 :
- Medical Oncology
Rakesh S. Shivatare has completed his Master in pharmacy (Pharmacognosy) at the age of 24 years from Pune University. He had worked as research officer and having 5 year experience in formulation analytical method development. He has published more than 15 papers in reputed national and international journals.
Cancer is the second leading cause of mortality worldwide. Overall, the prevalence of cancer has actually increased; just in the United States alone, approximately 1,665,540 people suffered from cancer, and 585,720 of them died due to this disease by 2014. Therefore, cancer is a serious problem affecting the health of all human societies. Unfortunately, it is a variety disease at the tissue level and this variety is a major challenge for its specific diagnosis, followed by efficacy of treatment.
In the current situation, we found that patients, survivors, and others may seek these types of information regardless of the type of cancer. In general, online cancer information or people discussion is expected to provide such information. Information needs regarding the side effects of treatment frequently appeared for colorectal, lung, esophageal, breast, and prostate cancers. Information needs regarding complementary and alternative medicine were frequent for gastric, lung, esophageal, and pancreatic cancers. Additionally, informational needs regarding pain were frequent for gastric, colorectal, lung, esophageal, pancreatic, and cervical cancers. These contents should be considered highly sought information across those tumor sites, and cancer-related websites should provide such information, based on scientific evidence.
Due to people’s discussion or Online cancer information materials, such as the websites of cancer related institutes, are generally expected to provide content regarding symptoms, disease stages, treatments, chance of cure, recovery, metastasis, and recurrence. These information may lead to achieve our target i.e. Battle Together For a Cancer Free World.
Sri Guru Ram Das University of Health sciences, Amritsar, India
Dr Neeraj Jain is Professor of Radiation Oncology at SGRD University of Health Sciences at Amritsar, India. He is well known in the region and has presented numerous papers in National and International conferences and lot of publication in his name. He is Vice President Of Association Of Radiation Oncologists Of India.
Head and neck cancer is one of the commonest malignancies in Indian males. Due to poor socioeconomic status presentation is usually in advanced stage. Only treatment option is Radiotherpy with or without chemotherapy.
IMRT provides highly conformal dose distributions creating non uniform spatial intensity using different segments in the beam.
Different retrospective studies have shown a high capability of IMRT to treat tumours close to the base of skull. Prospective studies have shown a decrease in xerostomia compared with conventional 3D conformal treatment (3DCRT). Modulation of intensity is performed by the movement of the multileaf collimator (MLC) that can deliver the radiation in different ways, such as static field segments, dynamic field segments and rotational delivery (arc therapy and tomotherapy). There are slight differences among the different techniques in terms of homogeneity, dose conformity and treatment delivery time.
The best method to deliver IMRT will depend on multiple factors such as deliverability, practicality, user training and plan quality.
Aim Of Study
To assess response and tolerability of treatment in elderly patients with locally advanced disease.
Material And Methods
During 2016-17, 44 patients with locally advanced head and neck cancers were treated with a curative intent with IMRT. They were in age range of 65-75. Median age was 69 years. 35 were male and 9 female. Histopathologically all had squamous cell carcinoma. Stage wise all were T3N2 or more.
There were no co morbid disease. No concurrent chemotherapy was given.
Patients were immobilised with orifit casts and Contrast CT were taken for simulation. Images were contoured and planned for IMRT. A dose of 70Gy in 35 fractions was planned. CBCT was taken every week and treatment plan verification was done.
. 6 patients had treatment interruptions due to toxicity. Incidence of mucositis was of gr1- 2 in all patients. No haematological toxicity was seen. Patients having dysphagia during treatment were given nasogastric feed.
Patients were assessed after 4 weeks of completion of treatment. Response wise 14 patients achived Complete response, 28 patients had partial response and 2 had stable disease. Therewas no treatment related mortality.
King Abdulaziz University, Saudi Arabia
Abdulrahman Mahdi Al-Ameer is a master student at King Abdulaziz University, Saudi Arabia.
Background: Tumor protein 53 is the most frequently mutated gene in human cancer. TP53 gene is located on the short arm of chromosome 17 and encodes for TP53 protein which plays a significant role in many cellular processes such as apoptosis, cell cycle arrest, genomic stability and DNA repair. In hematological malignancies, the prevalence of p53 mutations is low compared to other tumors but associated with a complex karyotype, poor prognosis and poor response to chemotherapy. Due to the lack of data in the prevalence and prognostic value of TP53 mutations among hematological malignancies in Saudi patients, we aimed in this study to evaluate the frequency and prognostic significance of TP53 mutations in different hematological malignancies in Jeddah, Saudi Arabia. Method: 10 samples from different hematological malignancies were tested for TP53 mutations using a next-generation platform. Results: 1/10 samples showed the incidence of a heterozygous mutation at codon 175 (exon 5) of the p53 gene that replaces histidine with arginine. The mutation was found in an MDS patient and associated with a complex karyotype and TP53 gene deletion.
Conclusion: The data showed that incidence of TP53 mutations in hematopoietic malignancies are infrequent which are consistent with the general observations. Interestingly, the mutation which we observed in our study was never been reported in the available p53 mutations databases, indicating the first discovery of this mutation. Further studies are needed to analyze a larger number of Saudi hematopoietic malignancies to find whether this mutation is unique in a certain population.
Director, Gaia Holistic Health USA
Graduated from Toho Academy of Music in Tokyo, as a pianist and composer, invited by the Boston Symphony, she came to the USA in 1961 as one of the first Japanese women. She then received Master of Art from New York University and finished her Ph.D. credits in Philosophy in 1965. In 1967, Tatsumura then turned to an independent career and became the top International Classical and Cultural Impresario/producer. Until 1992, she produced an average of 2,000 cultural events each year, traveling to more than 140 countries. She was presented with numerous honors for her work from different countries, many for humanitarian causes. She is also well known as a philanthropist.
INTRODUCTION Onnetsu means comfortable heat. Onnetsu Therapy invented by Dr. Kazuko Tatsumura emits from a special patented ceramic; 1) Heat 2) Precise 8-10µ of vibration of Far Infrared SunRay and 3) Vibration of Terahertz. Dr. Tatsumura is the first in the world to incorporate Terahertz minerals to medical use from active volcanos stones from Japan. Worldwide patent pending.
METHODS When Onnetsuki is slid over the skin, healthy areas are comfortable, but IF deep tissue is unhealthy or cold, degenerated, patient feels this spot to be ‘hot’. When this ‘hot spot’ is effectively treated with Onnetsu Therapy (Far-Infrared & Terahertz vibrations, and Heat), the hot sensation subsides and the Disease Conditions improve through vibrating water molecules of our deep tissue. Therefore, the Onnetsu Therapy is both a diagnostic and therapeutic. Dr Kazuko’s Onnetsu Therapy is based on four historical and scientific facts. 1. Traditional Japanese Concept of the significance of Body Temperature. Hippocrates also has left quotes on Heat. 2. NASA's finding regarding Far-Infrared vibration from Sun light precise 8-10µ. Also, added is the specific Terahertz vibration of earth minerals from volcanos stones from the depth of our planet earth. 3. Immunology by Dr. Toru Abo, balancing autonomic nervous system to improve condition of white cells; Raising Immunity. 4. Promoting four flows of Energy throughout our body by using acupuncture meridian technique.
RESULT Some countries (Peru, Cuba & Mexico) are practicing it in the hospitals and clinics. Clinical trials have shown improvements on many diseases: such as asthma, brain, ear & eye problems, cancers, diabetes, rheumatoid arthritis, tuberculosis and various pain conditions. Clinical studies from Cuba and Peru will be presented.
CONCLUSION Onnetsu Therapy is a new, easy & noninvasive treatment modality to treat difficult chronic medical conditions. Therapy uses Universal Vibrations, Heat, Light, Autonomic Nervous System Balance and Acupuncture Meridian System. Dr. Kazuko has taught Onnetsu Therapy to MDs and health practitioners over past decades throughout the world.